Molecular mechanisms of antitumor effect of natural antimicrobial peptides
- Authors: Balandin S.V.1, Emelianova A.A.1, Kalashnikova M.B.1, Kokryakov V.N.2,3, Shamova O.V.2,3, Ovchinnikova T.V.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Experimental Medicine
- St. Petersburg State University
- Issue: Vol 42, No 6 (2016)
- Pages: 575-589
- Section: Review Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228175
- DOI: https://doi.org/10.1134/S1068162016060029
- ID: 228175
Cite item
Abstract
In spite of all the advances in cancer treatment made in recent years, one of the main problems in this field that remains extremely urgent is the development of drug resistance to the chemotherapeutic agents currently in use due to clonal microevolution of tumor tissue. Numerous publications devoted to the study of cationic antimicrobial peptides (AMPs) as molecular factors of the innate immune system suggest that these compounds possess significant therapeutic potential and can be considered as candidates for the role of not only antimicrobial, but also next-generation anticancer drugs. AMPs are characterized by a variety of mechanisms of cytotoxic action that can lead to either necrosis or apoptosis of the target cells. These effects are based on the selective interaction with the membranes of tumor cells, which have a number of similarities, in structural and physiological aspects, with the microbial membranes. AMPs were found to be able to inhibit tumor growth by interrupting the formation of its vascular network. The antitumor effect of AMPs may also be enhanced by the modulation of host immune system, as previously observed for their antimicrobial effects. The described properties of AMPs give hope for the development of new drugs that will be able to overcome the resistance of tumor cells.
About the authors
S. V. Balandin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ovch@ibch.ru
Russian Federation, Moscow, 117997
A. A. Emelianova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ovch@ibch.ru
Russian Federation, Moscow, 117997
M. B. Kalashnikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ovch@ibch.ru
Russian Federation, Moscow, 117997
V. N. Kokryakov
Institute of Experimental Medicine; St. Petersburg State University
Email: ovch@ibch.ru
Russian Federation, St. Petersburg, 197376; St. Petersburg, 199034
O. V. Shamova
Institute of Experimental Medicine; St. Petersburg State University
Email: ovch@ibch.ru
Russian Federation, St. Petersburg, 197376; St. Petersburg, 199034
T. V. Ovchinnikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: ovch@ibch.ru
Russian Federation, Moscow, 117997