Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model
- Авторы: Sivak K.1, Stosman K.1, Muzhikyan A.1, Alexandrov A.1, Viktorov N.2, Vaulina D.3, Gomzina N.3
-
Учреждения:
- Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
- St. Petersburg State Technological Institute (Technical University)
- Bechterev Institute of Human Brain, Russian Academy of Science
- Выпуск: Том 45, № 5 (2019)
- Страницы: 425-429
- Раздел: Letter to Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/229230
- DOI: https://doi.org/10.1134/S1068162019040113
- ID: 229230
Цитировать
Аннотация
The synthesis of two derivatives of lignan 4'-O-methylhonokiol (MH), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol (III) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl (VI) has been described. Derivative (VI) demonstrates the highest anti-inflammatory activity in the lipopolysaccharide-induced (LPS-induced) neuroinflammation mouse model. Its effect on the morphological changes in the brain is comparable to that of celecoxib, a well-known nonsteroid anti-inflammatory drug and a selective inhibitor of cyclooxygenase-2 (COX 2).
Ключевые слова
Об авторах
K. Sivak
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 197376
K. Stosman
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 197376
A. Muzhikyan
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 197376
A. Alexandrov
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 197376
N. Viktorov
St. Petersburg State Technological Institute (Technical University)
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 190013
D. Vaulina
Bechterev Institute of Human Brain, Russian Academy of Science
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 197376
N. Gomzina
Bechterev Institute of Human Brain, Russian Academy of Science
Автор, ответственный за переписку.
Email: gomzina@ihb.spb.ru
Россия, St. Petersburg, 197376