Email this article Evaluation of Antiinflammatory Activity of 4'-О-Methylhonokiol Derivatives in a Neuroinflammation Model
- Authors: Sivak K.V.1, Stosman K.I.1, Muzhikyan A.A.1, Alexandrov A.G.1, Viktorov N.B.2, Vaulina D.D.3, Gomzina N.A.3
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Affiliations:
- Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
- St. Petersburg State Technological Institute (Technical University)
- Bechterev Institute of Human Brain, Russian Academy of Science
- Issue: Vol 45, No 5 (2019)
- Pages: 425-429
- Section: Letter to Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/229230
- DOI: https://doi.org/10.1134/S1068162019040113
- ID: 229230
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Abstract
The synthesis of two derivatives of lignan 4'-O-methylhonokiol (MH), i.e., 4'-methoxy-5-propyl-1,1'-biphenyl-2-ol (III) and 4'-(2-fluoroethoxy)-2-hydroxy-5-propyl-1,1'-biphenyl (VI) has been described. Derivative (VI) demonstrates the highest anti-inflammatory activity in the lipopolysaccharide-induced (LPS-induced) neuroinflammation mouse model. Its effect on the morphological changes in the brain is comparable to that of celecoxib, a well-known nonsteroid anti-inflammatory drug and a selective inhibitor of cyclooxygenase-2 (COX 2).
About the authors
K. V. Sivak
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 197376
K. I. Stosman
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 197376
A. A. Muzhikyan
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 197376
A. G. Alexandrov
Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 197376
N. B. Viktorov
St. Petersburg State Technological Institute (Technical University)
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 190013
D. D. Vaulina
Bechterev Institute of Human Brain, Russian Academy of Science
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 197376
N. A. Gomzina
Bechterev Institute of Human Brain, Russian Academy of Science
Author for correspondence.
Email: gomzina@ihb.spb.ru
Russian Federation, St. Petersburg, 197376
