6-Nitrotriazolo[1,5-a]pyrimidines as promising structures for pharmacotherapy of septic conditions
- Авторы: Savateev K.1, Ulomsky E.1, Fedotov V.1, Rusinov V.1, Sivak K.2, Lyubishin M.2, Kuzmich N.2, Aleksandrov A.1
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Учреждения:
- Boris Yeltsin Federal University, Department of Organic Chemistry
- Research Institute of Influenza
- Выпуск: Том 43, № 4 (2017)
- Страницы: 421-428
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228592
- DOI: https://doi.org/10.1134/S1068162017040094
- ID: 228592
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Аннотация
Promising 6-nitro-1,2,4-triazolo[1,5-a]pyrimidine analogues, structural analogues of synthetic inhibitors of adenosine receptors, were sorted out on the basis of quantum-chemical calculations. The compounds were synthesized by nitration and chlorodeoxygenation reactions. The in vivo activity of 6-nitroheterocycles was studied and the affinity to adenosine receptor A2A was demonstrated in regard to septic conditions.
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Об авторах
K. Savateev
Boris Yeltsin Federal University, Department of Organic Chemistry
Email: ulomsky@yandex.ru
Россия, Yekaterinburg, 620002
E. Ulomsky
Boris Yeltsin Federal University, Department of Organic Chemistry
Автор, ответственный за переписку.
Email: ulomsky@yandex.ru
Россия, Yekaterinburg, 620002
V. Fedotov
Boris Yeltsin Federal University, Department of Organic Chemistry
Email: ulomsky@yandex.ru
Россия, Yekaterinburg, 620002
V. Rusinov
Boris Yeltsin Federal University, Department of Organic Chemistry
Email: ulomsky@yandex.ru
Россия, Yekaterinburg, 620002
K. Sivak
Research Institute of Influenza
Email: ulomsky@yandex.ru
Россия, St. Petersburg, 197376
M. Lyubishin
Research Institute of Influenza
Email: ulomsky@yandex.ru
Россия, St. Petersburg, 197376
N. Kuzmich
Research Institute of Influenza
Email: ulomsky@yandex.ru
Россия, St. Petersburg, 197376
A. Aleksandrov
Boris Yeltsin Federal University, Department of Organic Chemistry
Email: ulomsky@yandex.ru
Россия, Yekaterinburg, 620002