6-Nitrotriazolo[1,5- a ]pyrimidines as promising structures for pharmacotherapy of septic conditions

K. V. Savateev; E. N. Ulomsky; V. V. Fedotov; V. L. Rusinov; K. V. Sivak; M. M. Lyubishin; N. N. Kuzmich; A. G. Aleksandrov

doi:10.1134/S1068162017040094

6-Nitrotriazolo[1,5-a]pyrimidines as promising structures for pharmacotherapy of septic conditions

Authors: Savateev K.V.¹, Ulomsky E.N.¹, Fedotov V.V.¹, Rusinov V.L.¹, Sivak K.V.², Lyubishin M.M.², Kuzmich N.N.², Aleksandrov A.G.¹
Affiliations:
1. Boris Yeltsin Federal University, Department of Organic Chemistry
2. Research Institute of Influenza
Issue: Vol 43, No 4 (2017)
Pages: 421-428
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/228592
DOI: https://doi.org/10.1134/S1068162017040094
ID: 228592

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Abstract

Promising 6-nitro-1,2,4-triazolo[1,5-a]pyrimidine analogues, structural analogues of synthetic inhibitors of adenosine receptors, were sorted out on the basis of quantum-chemical calculations. The compounds were synthesized by nitration and chlorodeoxygenation reactions. The in vivo activity of 6-nitroheterocycles was studied and the affinity to adenosine receptor A_2A was demonstrated in regard to septic conditions.