5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth
- Авторы: Alexandrova L.1, Efremenkova O.2, Andronova V.3, Galegov G.3, Solyev P.1, Karpenko I.1, Kochetkov S.1
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Учреждения:
- Engelhardt Institute of Molecular Biology
- Gause Institute of New Antibiotics
- Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
- Выпуск: Том 42, № 6 (2016)
- Страницы: 677-684
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228241
- DOI: https://doi.org/10.1134/S1068162016050022
- ID: 228241
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Аннотация
A series of 5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine have been synthesized by the interaction of 3′,5′-diacetyl-5-azidomethyl-2′-deoxyuridine with the corresponding 1-alkynes in a biphasic methylene chloride—water system catalyzed by Cu(I) followed by the deblocking with a water-alcohol ammonia solution. A low cytotoxicity of the compounds in Vero, Jurkat, and A549 cell cultures has been shown. The 2′-deoxyuridine derivatives exhibited an antiherpetic activity in vitro toward two laboratory strains of human herpes simplex virus type 1 (HSV-1): acyclovir-sensitive (HSV-1/L2) and acyclovir-resistant (HSV-1/L2RACV). They also inhibited the growth of some bacteria (Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus, and Leuconostoc mesenteroides) and yeasts Saccharomyces cerevisiae in vitro.
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Об авторах
L. Alexandrova
Engelhardt Institute of Molecular Biology
Автор, ответственный за переписку.
Email: ala2004_07@mail.ru
Россия, ul. Vavilova 32, Moscow, 119991
O. Efremenkova
Gause Institute of New Antibiotics
Email: ala2004_07@mail.ru
Россия, ul. Bol’shaya Pirogovskaya 11, Moscow, 119021
V. Andronova
Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
Email: ala2004_07@mail.ru
Россия, Moscow, 123098
G. Galegov
Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
Email: ala2004_07@mail.ru
Россия, Moscow, 123098
P. Solyev
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Россия, ul. Vavilova 32, Moscow, 119991
I. Karpenko
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Россия, ul. Vavilova 32, Moscow, 119991
S. Kochetkov
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Россия, ul. Vavilova 32, Moscow, 119991