5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth
- Authors: Alexandrova L.A.1, Efremenkova O.V.2, Andronova V.L.3, Galegov G.A.3, Solyev P.N.1, Karpenko I.L.1, Kochetkov S.N.1
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Affiliations:
- Engelhardt Institute of Molecular Biology
- Gause Institute of New Antibiotics
- Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
- Issue: Vol 42, No 6 (2016)
- Pages: 677-684
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228241
- DOI: https://doi.org/10.1134/S1068162016050022
- ID: 228241
Cite item
Abstract
A series of 5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine have been synthesized by the interaction of 3′,5′-diacetyl-5-azidomethyl-2′-deoxyuridine with the corresponding 1-alkynes in a biphasic methylene chloride—water system catalyzed by Cu(I) followed by the deblocking with a water-alcohol ammonia solution. A low cytotoxicity of the compounds in Vero, Jurkat, and A549 cell cultures has been shown. The 2′-deoxyuridine derivatives exhibited an antiherpetic activity in vitro toward two laboratory strains of human herpes simplex virus type 1 (HSV-1): acyclovir-sensitive (HSV-1/L2) and acyclovir-resistant (HSV-1/L2RACV). They also inhibited the growth of some bacteria (Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus, and Leuconostoc mesenteroides) and yeasts Saccharomyces cerevisiae in vitro.
About the authors
L. A. Alexandrova
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: ala2004_07@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
O. V. Efremenkova
Gause Institute of New Antibiotics
Email: ala2004_07@mail.ru
Russian Federation, ul. Bol’shaya Pirogovskaya 11, Moscow, 119021
V. L. Andronova
Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
Email: ala2004_07@mail.ru
Russian Federation, Moscow, 123098
G. A. Galegov
Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
Email: ala2004_07@mail.ru
Russian Federation, Moscow, 123098
P. N. Solyev
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
I. L. Karpenko
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
S. N. Kochetkov
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991