5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth
- Авторлар: Alexandrova L.1, Efremenkova O.2, Andronova V.3, Galegov G.3, Solyev P.1, Karpenko I.1, Kochetkov S.1
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Мекемелер:
- Engelhardt Institute of Molecular Biology
- Gause Institute of New Antibiotics
- Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
- Шығарылым: Том 42, № 6 (2016)
- Беттер: 677-684
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228241
- DOI: https://doi.org/10.1134/S1068162016050022
- ID: 228241
Дәйексөз келтіру
Аннотация
A series of 5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine have been synthesized by the interaction of 3′,5′-diacetyl-5-azidomethyl-2′-deoxyuridine with the corresponding 1-alkynes in a biphasic methylene chloride—water system catalyzed by Cu(I) followed by the deblocking with a water-alcohol ammonia solution. A low cytotoxicity of the compounds in Vero, Jurkat, and A549 cell cultures has been shown. The 2′-deoxyuridine derivatives exhibited an antiherpetic activity in vitro toward two laboratory strains of human herpes simplex virus type 1 (HSV-1): acyclovir-sensitive (HSV-1/L2) and acyclovir-resistant (HSV-1/L2RACV). They also inhibited the growth of some bacteria (Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus, and Leuconostoc mesenteroides) and yeasts Saccharomyces cerevisiae in vitro.
Негізгі сөздер
Авторлар туралы
L. Alexandrova
Engelhardt Institute of Molecular Biology
Хат алмасуға жауапты Автор.
Email: ala2004_07@mail.ru
Ресей, ul. Vavilova 32, Moscow, 119991
O. Efremenkova
Gause Institute of New Antibiotics
Email: ala2004_07@mail.ru
Ресей, ul. Bol’shaya Pirogovskaya 11, Moscow, 119021
V. Andronova
Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
Email: ala2004_07@mail.ru
Ресей, Moscow, 123098
G. Galegov
Ivanovskii Research Institute of Virology, Gamaleya Federal Research Center for Epidemiology and Microbiology
Email: ala2004_07@mail.ru
Ресей, Moscow, 123098
P. Solyev
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Ресей, ul. Vavilova 32, Moscow, 119991
I. Karpenko
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Ресей, ul. Vavilova 32, Moscow, 119991
S. Kochetkov
Engelhardt Institute of Molecular Biology
Email: ala2004_07@mail.ru
Ресей, ul. Vavilova 32, Moscow, 119991