Synthesis of Pyridyl-4-Oxy-Substituted N-Hydroxy Amides of Cinnamic Acid as New Inhibitors of Histone Deacetylase Activity and Hepatitis C Virus Replication
- Autores: Kozlov M.1, Malikova A.1, Kamarova K.1, Konduktorov K.1, Kochetkov S.1
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Afiliações:
- Engelhardt Institute of Molecular Biology
- Edição: Volume 44, Nº 4 (2018)
- Páginas: 453-460
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228984
- DOI: https://doi.org/10.1134/S1068162018040118
- ID: 228984
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Resumo
Three structural isomers of pyridyl-4-oxy-substituted N-hydroxy amides of cinnamic acid (PyOCHA) have been synthesized for the first time. The relationship between their antiviral activity against hepatitis C virus (HCV) and inhibition of histone deacetylases of different cellular localization has been studied.
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Sobre autores
M. Kozlov
Engelhardt Institute of Molecular Biology
Autor responsável pela correspondência
Email: kozlovmavi@gmail.com
Rússia, Moscow, 119991
A. Malikova
Engelhardt Institute of Molecular Biology
Email: kozlovmavi@gmail.com
Rússia, Moscow, 119991
K. Kamarova
Engelhardt Institute of Molecular Biology
Email: kozlovmavi@gmail.com
Rússia, Moscow, 119991
K. Konduktorov
Engelhardt Institute of Molecular Biology
Email: kozlovmavi@gmail.com
Rússia, Moscow, 119991
S. Kochetkov
Engelhardt Institute of Molecular Biology
Email: kozlovmavi@gmail.com
Rússia, Moscow, 119991