Synthesis of Pyridyl-4-Oxy-Substituted  N -Hydroxy Amides of Cinnamic Acid as New Inhibitors of Histone Deacetylase Activity and Hepatitis C Virus Replication

M. V. Kozlov; A. Z. Malikova; K. A. Kamarova; K. A. Konduktorov; S. N. Kochetkov

doi:10.1134/S1068162018040118

Synthesis of Pyridyl-4-Oxy-Substituted N-Hydroxy Amides of Cinnamic Acid as New Inhibitors of Histone Deacetylase Activity and Hepatitis C Virus Replication

Authors: Kozlov M.V.¹, Malikova A.Z.¹, Kamarova K.A.¹, Konduktorov K.A.¹, Kochetkov S.N.¹
Affiliations:
1. Engelhardt Institute of Molecular Biology
Issue: Vol 44, No 4 (2018)
Pages: 453-460
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/228984
DOI: https://doi.org/10.1134/S1068162018040118
ID: 228984

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Abstract

Three structural isomers of pyridyl-4-oxy-substituted N-hydroxy amides of cinnamic acid (PyOCHA) have been synthesized for the first time. The relationship between their antiviral activity against hepatitis C virus (HCV) and inhibition of histone deacetylases of different cellular localization has been studied.