The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities
- Autores: Popov L.1, Zubenko A.2, Fetisov L.2, Drobin Y.2, Klimenko A.3, Bodryakov A.2, Borodkin S.1, Melkozerova I.4
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Afiliações:
- Department of Chemistry
- North-Caucasian Zonal Scientific Research Veterinary Institute
- Don State Agrarian University
- Rostov-on-Don Basic Medical College
- Edição: Volume 44, Nº 2 (2018)
- Páginas: 238-243
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228896
- DOI: https://doi.org/10.1134/S1068162018010132
- ID: 228896
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Resumo
A series of new 1,3,4-oxadiazol-2-yl-acrylic acids was synthesized by cyclization of 4-(2-R-hydrazino)- 4-oxo-2-butenic acids, and their antibacterial and protistocidal activities were studied. The p-substituted benzyl derivatives in the Z-form were shown to exhibit a high protistocidal activity, which exceeded that of the reference drug Baycox (toltrazuril) by several times, whereas the 3-hydroxy-2-naphthyl derivative, in addition to a very high protistocidal activity, also exhibited a moderate antibacterial activity.
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Sobre autores
L. Popov
Department of Chemistry
Autor responsável pela correspondência
Email: ldpopov@mail.ru
Rússia, Rostov-on-Don, 344090
A. Zubenko
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Rússia, Novocherkassk, 346421
L. Fetisov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Rússia, Novocherkassk, 346421
Yu. Drobin
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Rússia, Novocherkassk, 346421
A. Klimenko
Don State Agrarian University
Email: ldpopov@mail.ru
Rússia, Persianovskii, 346493
A. Bodryakov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Rússia, Novocherkassk, 346421
S. Borodkin
Department of Chemistry
Email: ldpopov@mail.ru
Rússia, Rostov-on-Don, 344090
I. Melkozerova
Rostov-on-Don Basic Medical College
Email: ldpopov@mail.ru
Rússia, Rostov-on-Don, 344022