The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities
- Authors: Popov L.D.1, Zubenko A.A.2, Fetisov L.N.2, Drobin Y.D.2, Klimenko A.I.3, Bodryakov A.N.2, Borodkin S.A.1, Melkozerova I.E.4
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Affiliations:
- Department of Chemistry
- North-Caucasian Zonal Scientific Research Veterinary Institute
- Don State Agrarian University
- Rostov-on-Don Basic Medical College
- Issue: Vol 44, No 2 (2018)
- Pages: 238-243
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228896
- DOI: https://doi.org/10.1134/S1068162018010132
- ID: 228896
Cite item
Abstract
A series of new 1,3,4-oxadiazol-2-yl-acrylic acids was synthesized by cyclization of 4-(2-R-hydrazino)- 4-oxo-2-butenic acids, and their antibacterial and protistocidal activities were studied. The p-substituted benzyl derivatives in the Z-form were shown to exhibit a high protistocidal activity, which exceeded that of the reference drug Baycox (toltrazuril) by several times, whereas the 3-hydroxy-2-naphthyl derivative, in addition to a very high protistocidal activity, also exhibited a moderate antibacterial activity.
About the authors
L. D. Popov
Department of Chemistry
Author for correspondence.
Email: ldpopov@mail.ru
Russian Federation, Rostov-on-Don, 344090
A. A. Zubenko
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Russian Federation, Novocherkassk, 346421
L. N. Fetisov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Russian Federation, Novocherkassk, 346421
Yu. D. Drobin
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Russian Federation, Novocherkassk, 346421
A. I. Klimenko
Don State Agrarian University
Email: ldpopov@mail.ru
Russian Federation, Persianovskii, 346493
A. N. Bodryakov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: ldpopov@mail.ru
Russian Federation, Novocherkassk, 346421
S. A. Borodkin
Department of Chemistry
Email: ldpopov@mail.ru
Russian Federation, Rostov-on-Don, 344090
I. E. Melkozerova
Rostov-on-Don Basic Medical College
Email: ldpopov@mail.ru
Russian Federation, Rostov-on-Don, 344022