Preparation of temozolomide-loaded polymer particles and study of their antitumor activity in models of glioma and melanoma
- Autores: Nikolskaya E.1, Zhunina O.1, Vasilenko E.2, Yabbarov N.1, Tereshchenko O.1, Sokol M.1, Popenko V.3, Severin E.1
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Afiliações:
- Russian Research Center for Molecular Diagnostics and Therapy
- Nizhny Novgorod State University
- Engelhardt Institute of Molecular Biology
- Edição: Volume 43, Nº 5 (2017)
- Páginas: 552-560
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228665
- DOI: https://doi.org/10.1134/S1068162017050090
- ID: 228665
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Resumo
Temozolomide (TMZ) is a cytostatic drug used in treatment of patients with malignant gliomas and melanomas. The development of innovative formulations for delivery of TMZ into target cells in order to reduce its systemic toxicity and gain prolonged effect is a topical problem of modern biotechnology and pharmacology. The article presents experimental data on development of the TMZ polymer-based formulation. The TMZ formulation presents nanoparticles with average size of 300 nm exhibiting high in vitro cytotoxic activity against melanoma and glioma cells (cell lines C6, U377MG, B16, and Mel-10). Melanoma (B16 cell line) bearing mice (C57Bl/61) treated by TMZ polymer nanoparticles revealed inhibition of tumor growth and increase of the animal lifespan. Also, loading of TMZ into the polymer particles was shown to decrease acute toxicity of the drug compared to the intact drug.
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Sobre autores
E. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy
Email: olga_yarova@bk.ru
Rússia, Moscow, 117149
O. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy
Autor responsável pela correspondência
Email: olga_yarova@bk.ru
Rússia, Moscow, 117149
E. Vasilenko
Nizhny Novgorod State University
Email: olga_yarova@bk.ru
Rússia, Nizhny Novgorod, 603950
N. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy
Email: olga_yarova@bk.ru
Rússia, Moscow, 117149
O. Tereshchenko
Russian Research Center for Molecular Diagnostics and Therapy
Email: olga_yarova@bk.ru
Rússia, Moscow, 117149
M. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
Email: olga_yarova@bk.ru
Rússia, Moscow, 117149
V. Popenko
Engelhardt Institute of Molecular Biology
Email: olga_yarova@bk.ru
Rússia, Moscow, 119991
E. Severin
Russian Research Center for Molecular Diagnostics and Therapy
Email: olga_yarova@bk.ru
Rússia, Moscow, 117149