Preparation of temozolomide-loaded polymer particles and study of their antitumor activity in models of glioma and melanoma


Дәйексөз келтіру

Толық мәтін

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

Temozolomide (TMZ) is a cytostatic drug used in treatment of patients with malignant gliomas and melanomas. The development of innovative formulations for delivery of TMZ into target cells in order to reduce its systemic toxicity and gain prolonged effect is a topical problem of modern biotechnology and pharmacology. The article presents experimental data on development of the TMZ polymer-based formulation. The TMZ formulation presents nanoparticles with average size of 300 nm exhibiting high in vitro cytotoxic activity against melanoma and glioma cells (cell lines C6, U377MG, B16, and Mel-10). Melanoma (B16 cell line) bearing mice (C57Bl/61) treated by TMZ polymer nanoparticles revealed inhibition of tumor growth and increase of the animal lifespan. Also, loading of TMZ into the polymer particles was shown to decrease acute toxicity of the drug compared to the intact drug.

Авторлар туралы

E. Nikolskaya

Russian Research Center for Molecular Diagnostics and Therapy

Email: olga_yarova@bk.ru
Ресей, Moscow, 117149

O. Zhunina

Russian Research Center for Molecular Diagnostics and Therapy

Хат алмасуға жауапты Автор.
Email: olga_yarova@bk.ru
Ресей, Moscow, 117149

E. Vasilenko

Nizhny Novgorod State University

Email: olga_yarova@bk.ru
Ресей, Nizhny Novgorod, 603950

N. Yabbarov

Russian Research Center for Molecular Diagnostics and Therapy

Email: olga_yarova@bk.ru
Ресей, Moscow, 117149

O. Tereshchenko

Russian Research Center for Molecular Diagnostics and Therapy

Email: olga_yarova@bk.ru
Ресей, Moscow, 117149

M. Sokol

Russian Research Center for Molecular Diagnostics and Therapy

Email: olga_yarova@bk.ru
Ресей, Moscow, 117149

V. Popenko

Engelhardt Institute of Molecular Biology

Email: olga_yarova@bk.ru
Ресей, Moscow, 119991

E. Severin

Russian Research Center for Molecular Diagnostics and Therapy

Email: olga_yarova@bk.ru
Ресей, Moscow, 117149

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