Design, synthesis, and anticancer evaluation of some novel thiourea, carbamimidothioic acid, oxazole, oxazolidine, and 2-amino-1-phenylpropyl-2-chloroacetate derived from L-norephedrine
- Autores: Abdel-Kader M.1, Ghorab M.1,2, Alsaid M.1, Alqasoumi S.1
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Afiliações:
- Department of Pharmacognosy, College of Pharmacy
- Department of Drug Radiation Research
- Edição: Volume 42, Nº 4 (2016)
- Páginas: 434-440
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228049
- DOI: https://doi.org/10.1134/S1068162016040026
- ID: 228049
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Resumo
A novel series of thiourea, carbamimidothioic acid, 4, 5-dihydrooxazole-2-thiol, oxazolidine-2thine, and 2-amino-1-phenylpropyl-2-chloroacetate derivatives was designed and synthesized using 2-amino-1-phenylpropan-1-ol (L-norephedrine) as a strategic starting material. The structures of the newly synthesized compounds were established by elemental analyses, IR, and 1H NMR and 13C NMR spectral data. The compounds were evaluated for their in vitro anticancer activity against various cancer cell lines. The corresponding acetamide, carbamimidothioic acid, and 2-2-amino-1-phenylpropyl-2-chloroacetate derivatives showed almost the same activity as the standard drug doxorubicin against human breast cancer cell line (MCF-7). Also, the acetamide and 2-thioxoimidazolidin-4-one derivatives exhibited higher activity than the reference drug doxorubicin against human colon cancer cell line (HCT 116).
Sobre autores
Maged Abdel-Kader
Department of Pharmacognosy, College of Pharmacy; Department of Pharmacognosy, College of Pharmacy
Email: mmsghorab@yahoo.com
Arábia Saudita, Al-Kharj; Alexandria
Mostafa Ghorab
Department of Pharmacognosy, College of Pharmacy; Department of Drug Radiation Research
Autor responsável pela correspondência
Email: mmsghorab@yahoo.com
Arábia Saudita, Riyadh, 11451; Nasr City, Cairo
Mansour Alsaid
Department of Pharmacognosy, College of Pharmacy
Email: mmsghorab@yahoo.com
Arábia Saudita, Riyadh, 11451
Saleh Alqasoumi
Department of Pharmacognosy, College of Pharmacy
Email: mmsghorab@yahoo.com
Arábia Saudita, Riyadh, 11451