Design, synthesis, and anticancer evaluation of some novel thiourea, carbamimidothioic acid, oxazole, oxazolidine, and 2-amino-1-phenylpropyl-2-chloroacetate derived from L-norephedrine
- 作者: Abdel-Kader M.1, Ghorab M.1,2, Alsaid M.1, Alqasoumi S.1
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隶属关系:
- Department of Pharmacognosy, College of Pharmacy
- Department of Drug Radiation Research
- 期: 卷 42, 编号 4 (2016)
- 页面: 434-440
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228049
- DOI: https://doi.org/10.1134/S1068162016040026
- ID: 228049
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详细
A novel series of thiourea, carbamimidothioic acid, 4, 5-dihydrooxazole-2-thiol, oxazolidine-2thine, and 2-amino-1-phenylpropyl-2-chloroacetate derivatives was designed and synthesized using 2-amino-1-phenylpropan-1-ol (L-norephedrine) as a strategic starting material. The structures of the newly synthesized compounds were established by elemental analyses, IR, and 1H NMR and 13C NMR spectral data. The compounds were evaluated for their in vitro anticancer activity against various cancer cell lines. The corresponding acetamide, carbamimidothioic acid, and 2-2-amino-1-phenylpropyl-2-chloroacetate derivatives showed almost the same activity as the standard drug doxorubicin against human breast cancer cell line (MCF-7). Also, the acetamide and 2-thioxoimidazolidin-4-one derivatives exhibited higher activity than the reference drug doxorubicin against human colon cancer cell line (HCT 116).
作者简介
Maged Abdel-Kader
Department of Pharmacognosy, College of Pharmacy; Department of Pharmacognosy, College of Pharmacy
Email: mmsghorab@yahoo.com
沙特阿拉伯, Al-Kharj; Alexandria
Mostafa Ghorab
Department of Pharmacognosy, College of Pharmacy; Department of Drug Radiation Research
编辑信件的主要联系方式.
Email: mmsghorab@yahoo.com
沙特阿拉伯, Riyadh, 11451; Nasr City, Cairo
Mansour Alsaid
Department of Pharmacognosy, College of Pharmacy
Email: mmsghorab@yahoo.com
沙特阿拉伯, Riyadh, 11451
Saleh Alqasoumi
Department of Pharmacognosy, College of Pharmacy
Email: mmsghorab@yahoo.com
沙特阿拉伯, Riyadh, 11451