The Synthesis and Biological Activity of 3,3'-Dimethyl-L-Selenocystine, a New Selenocystine Derivative
- Авторлар: Poluboyarinov P.1, Golubkina N.2, Aniskov A.3, Moiseeva I.4, Glebova N.4, Shvets V.5
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Мекемелер:
- Penza State University of Architecture and Construction
- Federal Scientific Center for Horticulture
- Saratov State University
- Penza State University
- Lomonosov Institute of Fine Chemical Technology
- Шығарылым: Том 45, № 4 (2019)
- Беттер: 241-247
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229201
- DOI: https://doi.org/10.1134/S1068162019040083
- ID: 229201
Дәйексөз келтіру
Аннотация
Using the known synthesis of L-selenocystine,3,3'-diseleno-bis (2-aminopropionic acid), from β‑chloroalanine, a structural analog of natural sulfur-containing amino acids capable of accumulating selenium in the body, we synthesized a new selenium-containing amino acid 3,3'-dimethyl-L-selenocystine () from α-amino-β-chlorobutyric acid. It was shown that, similarly to the selenium released from natural L-selenocystine, the selenium from 3,3'-dimethyl-L-selenocystine accumulated in rat liver, muscles, and serum, where its concentration exceeded that of the control by 40.63, 14.07 and 22.98%, respectively. A close degree of selenium accumulation in the tissues implied a similar metabolic pathway of the amino acids and biological availability of the trace element from the synthesized amino acid. L-Selenocystine and 3,3'‑dimethyl-L-selenocystine decreased concentrations of free amino acids in rat serum by 12.17 and 11.78%, respectively. The most significant reduction, by 74.6 and 66.4% respectively, was observed for proline, a marker of organism stress. Accumulation of selenium in liver and serum indicated close metabolism of L‑selenocystine and its derivative 3,3'-dimethyl-L-selenocystine.
Негізгі сөздер
Авторлар туралы
P. Poluboyarinov
Penza State University of Architecture and Construction
Хат алмасуға жауапты Автор.
Email: poluboyarinovpavel@yandex.ru
Ресей, Penza, 440028
N. Golubkina
Federal Scientific Center for Horticulture
Email: poluboyarinovpavel@yandex.ru
Ресей, VNIISSOK, Odintsovo district, Moscow oblast, 143072
A. Aniskov
Saratov State University
Email: poluboyarinovpavel@yandex.ru
Ресей, Saratov, 410012
I. Moiseeva
Penza State University
Email: poluboyarinovpavel@yandex.ru
Ресей, Penza, 440026
N. Glebova
Penza State University
Email: poluboyarinovpavel@yandex.ru
Ресей, Penza, 440026
V. Shvets
Lomonosov Institute of Fine Chemical Technology
Email: poluboyarinovpavel@yandex.ru
Ресей, Moscow, 119571