Erratum to: “DNA sequence-specific ligands: XVI. Series of the DBP(n) fluorescent dimeric bisbenzimidazoles with 1,4-piperazine-containing linkers”
- Authors: Koval V.S.1, Ivanov A.A.2, Salyanov V.I.1, Stomakhin A.A.1, Oleinikov V.A.3, Zhuze A.L.1
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Affiliations:
- Engelhardt Institute of Molecular Biology
- Blokhin Russian Cancer Research Center
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 43, No 6 (2017)
- Pages: 690-690
- Section: Erratum
- URL: https://journals.rcsi.science/1068-1620/article/view/228748
- DOI: https://doi.org/10.1134/S1068162017060036
- ID: 228748
Cite item
Abstract
A novel series of the DBP(n) fluorescent symmetric dimeric bisbenzimidazoles in which the bisbenzimidazole fragments were attached to an oligomeric linker with the 1,4-piperazine residue in its center were prepared. The DBP(n) molecules were distinguished by the number of methylene groups n (where n = 1, 2, 3, 4) in the linker. The DBP(n) synthesis was based on a condensation of the monomeric bisbenzimidazole (MB) with 1,4-piperazinedialkylcarbonic acids. The ability of the DBP(n) dimeric bisbenzimidazoles to form complexes with the double-stranded DNA was demonstrated by a complex of physicochemical methods, including spectroscopy in the visual UV-area, circular dichroism (CD), and fluorescence. The DBP(1–4) molecules were localized in the DNA minor groove by the CD method with the use of cholesteric liquid-crystalline dispersions (CLCD) of the double-stranded DNA. The DBP(n) dimeric bisbenzimidazoles were easily soluble in water, penetrated through cellular and nuclear membranes, and stained DNA in living cells distinct from the previously synthesized DB(n) series.
About the authors
V. S. Koval
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Russian Federation, Moscow, 119991
A. A. Ivanov
Blokhin Russian Cancer Research Center
Email: zhuze@eimb.ru
Russian Federation, Moscow, 115478
V. I. Salyanov
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Russian Federation, Moscow, 119991
A. A. Stomakhin
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Russian Federation, Moscow, 119991
V. A. Oleinikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: zhuze@eimb.ru
Russian Federation, Moscow, 117997
A. L. Zhuze
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: zhuze@eimb.ru
Russian Federation, Moscow, 119991