Erratum to: “DNA sequence-specific ligands: XVI. Series of the DBP(n) fluorescent dimeric bisbenzimidazoles with 1,4-piperazine-containing linkers”
- Авторы: Koval V.1, Ivanov A.2, Salyanov V.1, Stomakhin A.1, Oleinikov V.3, Zhuze A.1
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Учреждения:
- Engelhardt Institute of Molecular Biology
- Blokhin Russian Cancer Research Center
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Выпуск: Том 43, № 6 (2017)
- Страницы: 690-690
- Раздел: Erratum
- URL: https://journals.rcsi.science/1068-1620/article/view/228748
- DOI: https://doi.org/10.1134/S1068162017060036
- ID: 228748
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Аннотация
A novel series of the DBP(n) fluorescent symmetric dimeric bisbenzimidazoles in which the bisbenzimidazole fragments were attached to an oligomeric linker with the 1,4-piperazine residue in its center were prepared. The DBP(n) molecules were distinguished by the number of methylene groups n (where n = 1, 2, 3, 4) in the linker. The DBP(n) synthesis was based on a condensation of the monomeric bisbenzimidazole (MB) with 1,4-piperazinedialkylcarbonic acids. The ability of the DBP(n) dimeric bisbenzimidazoles to form complexes with the double-stranded DNA was demonstrated by a complex of physicochemical methods, including spectroscopy in the visual UV-area, circular dichroism (CD), and fluorescence. The DBP(1–4) molecules were localized in the DNA minor groove by the CD method with the use of cholesteric liquid-crystalline dispersions (CLCD) of the double-stranded DNA. The DBP(n) dimeric bisbenzimidazoles were easily soluble in water, penetrated through cellular and nuclear membranes, and stained DNA in living cells distinct from the previously synthesized DB(n) series.
Об авторах
V. Koval
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Россия, Moscow, 119991
A. Ivanov
Blokhin Russian Cancer Research Center
Email: zhuze@eimb.ru
Россия, Moscow, 115478
V. Salyanov
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Россия, Moscow, 119991
A. Stomakhin
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Россия, Moscow, 119991
V. Oleinikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: zhuze@eimb.ru
Россия, Moscow, 117997
A. Zhuze
Engelhardt Institute of Molecular Biology
Автор, ответственный за переписку.
Email: zhuze@eimb.ru
Россия, Moscow, 119991