Email this article Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides
- Authors: Tatulchenkov M.Y.1, Prokhorenko I.A.2,3, Kvach M.V.1, Navakouski M.E.4, Stepanova I.A.2, Pilchenko N.V.1,4, Gontarev S.V.4, Sharko O.L.1, Korshun V.A.2,3, Shmanai V.V.1
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Affiliations:
- Institute of Physical Organic Chemistry
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Gauze Institute of New Antibiotics
- ALC Primetech
- Issue: Vol 43, No 4 (2017)
- Pages: 386-396
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228580
- DOI: https://doi.org/10.1134/S1068162017040148
- ID: 228580
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Abstract
The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain has been described. The efficiency of the reagents and supports has been confirmed by the synthesis of the corresponding modified oligonucleotides.
About the authors
M. Yu. Tatulchenkov
Institute of Physical Organic Chemistry
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072
I. A. Prokhorenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Gauze Institute of New Antibiotics
Email: shmanai@ifoch.bas-net.by
Russian Federation, Moscow, 117997; Moscow, 119021
M. V. Kvach
Institute of Physical Organic Chemistry
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072
M. E. Navakouski
ALC Primetech
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072
I. A. Stepanova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: shmanai@ifoch.bas-net.by
Russian Federation, Moscow, 117997
N. V. Pilchenko
Institute of Physical Organic Chemistry; ALC Primetech
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072; Minsk, 220072
S. V. Gontarev
ALC Primetech
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072
O. L. Sharko
Institute of Physical Organic Chemistry
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072
V. A. Korshun
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Gauze Institute of New Antibiotics
Email: shmanai@ifoch.bas-net.by
Russian Federation, Moscow, 117997; Moscow, 119021
V. V. Shmanai
Institute of Physical Organic Chemistry
Author for correspondence.
Email: shmanai@ifoch.bas-net.by
Belarus, Minsk, 220072
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