Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides

M. Yu. Tatulchenkov; I. A. Prokhorenko; M. V. Kvach; M. E. Navakouski; I. A. Stepanova; N. V. Pilchenko; S. V. Gontarev; O. L. Sharko; V. A. Korshun; V. V. Shmanai

doi:10.1134/S1068162017040148

Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides

Autores: Tatulchenkov M.Y.¹, Prokhorenko I.A.²^,3, Kvach M.V.¹, Navakouski M.E.⁴, Stepanova I.A.², Pilchenko N.V.¹^,4, Gontarev S.V.⁴, Sharko O.L.¹, Korshun V.A.²^,3, Shmanai V.V.¹
Afiliações:
1. Institute of Physical Organic Chemistry
2. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
3. Gauze Institute of New Antibiotics
4. ALC Primetech
Edição: Volume 43, Nº 4 (2017)
Páginas: 386-396
Seção: Article
URL: https://journals.rcsi.science/1068-1620/article/view/228580
DOI: https://doi.org/10.1134/S1068162017040148
ID: 228580

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The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain has been described. The efficiency of the reagents and supports has been confirmed by the synthesis of the corresponding modified oligonucleotides.