Synthesis of 9-bromocotarnine and its recyclization into 4-acyl-9-bromo-7,8-methylenedioxy-1,2-dihydro-3-benzazepines with anti-infective activity
- Authors: Zubenko A.A.1, Divaeva L.N.2, Morkovnik A.S.2, Kartsev V.G.3, Drobin Y.D.1, Serbinovskaya N.M.1, Fetisov L.N.1, Bodryakov A.N.1, Bodryakova M.A.1, Lyashenko L.A.1
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Affiliations:
- North-Caucasian Zonal Scientific Research Veterinary Institute
- Institute of Organic and Physical Chemistry
- InterBioScreen Ltd
- Issue: Vol 43, No 3 (2017)
- Pages: 311-316
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228533
- DOI: https://doi.org/10.1134/S1068162017030189
- ID: 228533
Cite item
Abstract
9-Bromocotarnine in the stable perchlorate form has been obtained by the interaction of cotarnine with bromine. The reaction of 9-bromocotarnine with α-haloketones is accompanied by the extension of the six-membered hetero-ring to seven-membered ring and led to previously unknown 4-acyl-9-bromo-3-methyl-6-methoxy-7,8-methylendioxy-1,2-dihydro-3-benzazepines. Some of these compounds have been shown to have only moderate antibacterial (against Staphylococcus aureus, Escherichia coli) and fungistatic (Penicillium italicum) activities, but none of them has been shown to have a pronounced protistocidal activity against Colpoda steinii.
About the authors
A. A. Zubenko
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. N. Divaeva
Institute of Organic and Physical Chemistry
Author for correspondence.
Email: divaevaln@mail.ru
Russian Federation, Rostov-on-Don, 344090
A. S. Morkovnik
Institute of Organic and Physical Chemistry
Email: divaevaln@mail.ru
Russian Federation, Rostov-on-Don, 344090
V. G. Kartsev
InterBioScreen Ltd
Email: divaevaln@mail.ru
Russian Federation, Moscow oblast, Chernogolovka
Y. D. Drobin
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
N. M. Serbinovskaya
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. N. Fetisov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
A. N. Bodryakov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
M. A. Bodryakova
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk
L. A. Lyashenko
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Russian Federation, Novocherkassk