Synthesis of 9-bromocotarnine and its recyclization into 4-acyl-9-bromo-7,8-methylenedioxy-1,2-dihydro-3-benzazepines with anti-infective activity
- Autores: Zubenko A.1, Divaeva L.2, Morkovnik A.2, Kartsev V.3, Drobin Y.1, Serbinovskaya N.1, Fetisov L.1, Bodryakov A.1, Bodryakova M.1, Lyashenko L.1
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Afiliações:
- North-Caucasian Zonal Scientific Research Veterinary Institute
- Institute of Organic and Physical Chemistry
- InterBioScreen Ltd
- Edição: Volume 43, Nº 3 (2017)
- Páginas: 311-316
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228533
- DOI: https://doi.org/10.1134/S1068162017030189
- ID: 228533
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Resumo
9-Bromocotarnine in the stable perchlorate form has been obtained by the interaction of cotarnine with bromine. The reaction of 9-bromocotarnine with α-haloketones is accompanied by the extension of the six-membered hetero-ring to seven-membered ring and led to previously unknown 4-acyl-9-bromo-3-methyl-6-methoxy-7,8-methylendioxy-1,2-dihydro-3-benzazepines. Some of these compounds have been shown to have only moderate antibacterial (against Staphylococcus aureus, Escherichia coli) and fungistatic (Penicillium italicum) activities, but none of them has been shown to have a pronounced protistocidal activity against Colpoda steinii.
Sobre autores
A. Zubenko
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk
L. Divaeva
Institute of Organic and Physical Chemistry
Autor responsável pela correspondência
Email: divaevaln@mail.ru
Rússia, Rostov-on-Don, 344090
A. Morkovnik
Institute of Organic and Physical Chemistry
Email: divaevaln@mail.ru
Rússia, Rostov-on-Don, 344090
V. Kartsev
InterBioScreen Ltd
Email: divaevaln@mail.ru
Rússia, Moscow oblast, Chernogolovka
Y. Drobin
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk
N. Serbinovskaya
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk
L. Fetisov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk
A. Bodryakov
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk
M. Bodryakova
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk
L. Lyashenko
North-Caucasian Zonal Scientific Research Veterinary Institute
Email: divaevaln@mail.ru
Rússia, Novocherkassk