The secreted protein Noggin4 is an activator of the Wnt/PCP-signaling pathway
- Authors: Bayramov A.V.1, Eroshkin F.M.1, Martynova N.Y.1, Orlov E.E.1, Borodulin A.V.1, Zaraisky A.G.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 43, No 2 (2017)
- Pages: 216-219
- Section: Letter to the Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/228497
- DOI: https://doi.org/10.1134/S1068162017020029
- ID: 228497
Cite item
Abstract
The protein Noggin4 of the African clawed frog Xenopus laevis has been shown to act as a modulator of the “noncanonical” Wnt/PCP-signaling pathway that plays an important role in the regulation of cell motility. Induction of disturbances in the expression of Noggin4 led to the activation of Wnt/PCP-pathway and the related anomalies of early embryonic development. The Noggin4 protein can bind the Wnt11 protein that normally contributes to the activation of the Wnt/PCP-pathway and of enhancing the activator effect of this protein in luciferase assays. Thus, Noggin4 can be used as a tool for specific experimental regulation of the activity of the Wnt/PCP pathway.
About the authors
A. V. Bayramov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: andrbayr@gmail.com
Russian Federation, Moscow, 117997
F. M. Eroshkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
Russian Federation, Moscow, 117997
N. Y. Martynova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
Russian Federation, Moscow, 117997
E. E. Orlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
Russian Federation, Moscow, 117997
A. V. Borodulin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
Russian Federation, Moscow, 117997
A. G. Zaraisky
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: azaraisky@yahoo.com
Russian Federation, Moscow, 117997