The secreted protein Noggin4 is an activator of the Wnt/PCP-signaling pathway
- 作者: Bayramov A.1, Eroshkin F.1, Martynova N.1, Orlov E.1, Borodulin A.1, Zaraisky A.1
-
隶属关系:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- 期: 卷 43, 编号 2 (2017)
- 页面: 216-219
- 栏目: Letter to the Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/228497
- DOI: https://doi.org/10.1134/S1068162017020029
- ID: 228497
如何引用文章
详细
The protein Noggin4 of the African clawed frog Xenopus laevis has been shown to act as a modulator of the “noncanonical” Wnt/PCP-signaling pathway that plays an important role in the regulation of cell motility. Induction of disturbances in the expression of Noggin4 led to the activation of Wnt/PCP-pathway and the related anomalies of early embryonic development. The Noggin4 protein can bind the Wnt11 protein that normally contributes to the activation of the Wnt/PCP-pathway and of enhancing the activator effect of this protein in luciferase assays. Thus, Noggin4 can be used as a tool for specific experimental regulation of the activity of the Wnt/PCP pathway.
作者简介
A. Bayramov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: andrbayr@gmail.com
俄罗斯联邦, Moscow, 117997
F. Eroshkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
俄罗斯联邦, Moscow, 117997
N. Martynova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
俄罗斯联邦, Moscow, 117997
E. Orlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
俄罗斯联邦, Moscow, 117997
A. Borodulin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: azaraisky@yahoo.com
俄罗斯联邦, Moscow, 117997
A. Zaraisky
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: azaraisky@yahoo.com
俄罗斯联邦, Moscow, 117997