Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase
- Authors: Grigorenko N.A.1, Khomutov M.A.1, Simonian A.R.1, Kochetkov S.N.1, Khomutov A.R.1
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Affiliations:
- Engelhardt Institute of Molecular Biology
- Issue: Vol 42, No 4 (2016)
- Pages: 423-427
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228033
- DOI: https://doi.org/10.1134/S1068162016030080
- ID: 228033
Cite item
Abstract
Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.
Keywords
About the authors
N. A. Grigorenko
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
M. A. Khomutov
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
A. R. Simonian
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
S. N. Kochetkov
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
A. R. Khomutov
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: alexkhom@list.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991