Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

N. A. Grigorenko; M. A. Khomutov; A. R. Simonian; S. N. Kochetkov; A. R. Khomutov

doi:10.1134/S1068162016030080

Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

Authors: Grigorenko N.A.¹, Khomutov M.A.¹, Simonian A.R.¹, Kochetkov S.N.¹, Khomutov A.R.¹
Affiliations:
1. Engelhardt Institute of Molecular Biology
Issue: Vol 42, No 4 (2016)
Pages: 423-427
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/228033
DOI: https://doi.org/10.1134/S1068162016030080
ID: 228033

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.