Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

N. A. Grigorenko; M. A. Khomutov; A. R. Simonian; S. N. Kochetkov; A. R. Khomutov

doi:10.1134/S1068162016030080

Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

作者: Grigorenko N.¹, Khomutov M.¹, Simonian A.¹, Kochetkov S.¹, Khomutov A.¹
隶属关系:
1. Engelhardt Institute of Molecular Biology
期: 卷 42, 编号 4 (2016)
页面: 423-427
栏目: Article
URL: https://journals.rcsi.science/1068-1620/article/view/228033
DOI: https://doi.org/10.1134/S1068162016030080
ID: 228033

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Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.