Synthesis of ( Z )- N -hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication

M. V. Kozlov; A. A. Kleymenova; K. A. Konduktorov; A. Z. Malikova; K. A. Kamarova; R. A. Novikov; S. N. Kochetkov

doi:10.1134/S1068162016010076

Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication

Authors: Kozlov M.V.¹, Kleymenova A.A.¹, Konduktorov K.A.¹, Malikova A.Z.¹, Kamarova K.A.¹, Novikov R.A.¹, Kochetkov S.N.¹
Affiliations:
1. Engelhardt Institute of Molecular Biology
Issue: Vol 42, No 2 (2016)
Pages: 191-197
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/227875
DOI: https://doi.org/10.1134/S1068162016010076
ID: 227875

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Abstract

According to recently published results, cinnamic hydroxamic acid (CHA) inhibits replication of hepatitis C virus (HCV). We synthesized a structural analogue of CHA, i.e., (Z)-N-hydroxy-3-methoxy3-phenylacrylamide, which inhibited HCV replication five times more selectively than CHA. It was found that both compounds did not inhibit deacetylation of Ac-α-tubulin with histone deacetylase 6, the activity of which is important for virus replication.