Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication
- Autores: Kozlov M.1, Kleymenova A.1, Konduktorov K.1, Malikova A.1, Kamarova K.1, Novikov R.1, Kochetkov S.1
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Afiliações:
- Engelhardt Institute of Molecular Biology
- Edição: Volume 42, Nº 2 (2016)
- Páginas: 191-197
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227875
- DOI: https://doi.org/10.1134/S1068162016010076
- ID: 227875
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Resumo
According to recently published results, cinnamic hydroxamic acid (CHA) inhibits replication of hepatitis C virus (HCV). We synthesized a structural analogue of CHA, i.e., (Z)-N-hydroxy-3-methoxy3-phenylacrylamide, which inhibited HCV replication five times more selectively than CHA. It was found that both compounds did not inhibit deacetylation of Ac-α-tubulin with histone deacetylase 6, the activity of which is important for virus replication.
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Sobre autores
M. Kozlov
Engelhardt Institute of Molecular Biology
Autor responsável pela correspondência
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991
A. Kleymenova
Engelhardt Institute of Molecular Biology
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991
K. Konduktorov
Engelhardt Institute of Molecular Biology
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991
A. Malikova
Engelhardt Institute of Molecular Biology
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991
K. Kamarova
Engelhardt Institute of Molecular Biology
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991
R. Novikov
Engelhardt Institute of Molecular Biology
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991
S. Kochetkov
Engelhardt Institute of Molecular Biology
Email: kozlovmv@hotmail.com
Rússia, ul. Vavilova 32, Moscow, 119991