Zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine as a new site-specific marker for serum albumin
- Authors: Lebedeva N.S.1, Yurina E.S.1, Gubarev Y.A.1, Mayzlish V.E.2,3
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Affiliations:
- Krestov Institute of Solution Chemistry
- Research Institute of Macroheterocycles
- Ivanovo State University of Chemistry and Technology
- Issue: Vol 42, No 1 (2016)
- Pages: 29-35
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227814
- DOI: https://doi.org/10.1134/S1068162015050143
- ID: 227814
Cite item
Abstract
The interaction of zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine with bovine serum albumin was studied via electron absorption spectroscopy and fluorescence spectroscopy. Being the associate in aqueous media, zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine is converted to its monomeric form to be bound to albumin, with the monomeric form of the phthalocyanine being characterized by a fluorescence in the visible region of the spectrum. The displacement titration of albumin complexes with the known site-specific markers (such as warfarin, L-tryptophan, and hemin) and phthalocyanine was performed to show the location of zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine within the IIA subdomain of albumin.
About the authors
N. Sh. Lebedeva
Krestov Institute of Solution Chemistry
Email: yurina_elena77@mail.ru
Russian Federation, Ivanovo, 153045
E. S. Yurina
Krestov Institute of Solution Chemistry
Author for correspondence.
Email: yurina_elena77@mail.ru
Russian Federation, Ivanovo, 153045
Yu. A. Gubarev
Krestov Institute of Solution Chemistry
Email: yurina_elena77@mail.ru
Russian Federation, Ivanovo, 153045
V. E. Mayzlish
Research Institute of Macroheterocycles; Ivanovo State University of Chemistry and Technology
Email: yurina_elena77@mail.ru
Russian Federation, Ivanovo, 153045; Ivanovo, 153045