Zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine as a new site-specific marker for serum albumin
- Авторы: Lebedeva N.1, Yurina E.1, Gubarev Y.1, Mayzlish V.2,3
-
Учреждения:
- Krestov Institute of Solution Chemistry
- Research Institute of Macroheterocycles
- Ivanovo State University of Chemistry and Technology
- Выпуск: Том 42, № 1 (2016)
- Страницы: 29-35
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227814
- DOI: https://doi.org/10.1134/S1068162015050143
- ID: 227814
Цитировать
Аннотация
The interaction of zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine with bovine serum albumin was studied via electron absorption spectroscopy and fluorescence spectroscopy. Being the associate in aqueous media, zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine is converted to its monomeric form to be bound to albumin, with the monomeric form of the phthalocyanine being characterized by a fluorescence in the visible region of the spectrum. The displacement titration of albumin complexes with the known site-specific markers (such as warfarin, L-tryptophan, and hemin) and phthalocyanine was performed to show the location of zinc tetra-4-(4'-carboxyphenoxy)phthalocyanine within the IIA subdomain of albumin.
Об авторах
N. Lebedeva
Krestov Institute of Solution Chemistry
Email: yurina_elena77@mail.ru
Россия, Ivanovo, 153045
E. Yurina
Krestov Institute of Solution Chemistry
Автор, ответственный за переписку.
Email: yurina_elena77@mail.ru
Россия, Ivanovo, 153045
Yu. Gubarev
Krestov Institute of Solution Chemistry
Email: yurina_elena77@mail.ru
Россия, Ivanovo, 153045
V. Mayzlish
Research Institute of Macroheterocycles; Ivanovo State University of Chemistry and Technology
Email: yurina_elena77@mail.ru
Россия, Ivanovo, 153045; Ivanovo, 153045