Synthesis and cytotoxicity of new alkyne derivatives of pentacyclic triterpenoids
- 作者: Yamansarov E.1, Saltykova I.1, Kovalev S.1, Petrov R.1, Shkil’ D.1, Seleznev E.1, Beloglazkina E.1, Majouga A.1,2,3
-
隶属关系:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- National University of Science and Technology MISIS
- D. Mendeleev University of Chemical Technology of Russia
- 期: 卷 68, 编号 4 (2019)
- 页面: 855-861
- 栏目: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243357
- DOI: https://doi.org/10.1007/s11172-019-2496-1
- ID: 243357
如何引用文章
详细
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined against HepG2 and Huh7 hepatocarcinoma cells and PC3 prostate cancer cells. The primary analysis of the structure—activity relationships was performed; glycyrrhetic acid derivatives showed the maximum enhancement in the cytotoxic properties upon introduction of an alkyne moiety.
作者简介
E. Yamansarov
Department of Chemistry, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
I. Saltykova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
S. Kovalev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
R. Petrov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
D. Shkil’
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Seleznev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991
A. Majouga
Department of Chemistry, M. V. Lomonosov Moscow State University; National University of Science and Technology MISIS; D. Mendeleev University of Chemical Technology of Russia
Email: jamansar@gmail.com
俄罗斯联邦, 3 Build., 1 Leninskie Gory, Moscow, 119991; 4 Leninskii prosp., Moscow, 119049; 1 Build., 9 Miusskaya pl., Moscow, 125047