Enviar artigo por via de e-mail Synthesis and cytotoxicity of new alkyne derivatives of pentacyclic triterpenoids
- Autores: Yamansarov E.1, Saltykova I.1, Kovalev S.1, Petrov R.1, Shkil’ D.1, Seleznev E.1, Beloglazkina E.1, Majouga A.1,2,3
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Afiliações:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- National University of Science and Technology MISIS
- D. Mendeleev University of Chemical Technology of Russia
- Edição: Volume 68, Nº 4 (2019)
- Páginas: 855-861
- Seção: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243357
- DOI: https://doi.org/10.1007/s11172-019-2496-1
- ID: 243357
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Resumo
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined against HepG2 and Huh7 hepatocarcinoma cells and PC3 prostate cancer cells. The primary analysis of the structure—activity relationships was performed; glycyrrhetic acid derivatives showed the maximum enhancement in the cytotoxic properties upon introduction of an alkyne moiety.
Sobre autores
E. Yamansarov
Department of Chemistry, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
I. Saltykova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
S. Kovalev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
R. Petrov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
D. Shkil’
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Seleznev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991
A. Majouga
Department of Chemistry, M. V. Lomonosov Moscow State University; National University of Science and Technology MISIS; D. Mendeleev University of Chemical Technology of Russia
Email: jamansar@gmail.com
Rússia, 3 Build., 1 Leninskie Gory, Moscow, 119991; 4 Leninskii prosp., Moscow, 119049; 1 Build., 9 Miusskaya pl., Moscow, 125047
