Synthesis and cytotoxicity of new alkyne derivatives of pentacyclic triterpenoids
- Авторлар: Yamansarov E.1, Saltykova I.1, Kovalev S.1, Petrov R.1, Shkil’ D.1, Seleznev E.1, Beloglazkina E.1, Majouga A.1,2,3
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Мекемелер:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- National University of Science and Technology MISIS
- D. Mendeleev University of Chemical Technology of Russia
- Шығарылым: Том 68, № 4 (2019)
- Беттер: 855-861
- Бөлім: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243357
- DOI: https://doi.org/10.1007/s11172-019-2496-1
- ID: 243357
Дәйексөз келтіру
Аннотация
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined against HepG2 and Huh7 hepatocarcinoma cells and PC3 prostate cancer cells. The primary analysis of the structure—activity relationships was performed; glycyrrhetic acid derivatives showed the maximum enhancement in the cytotoxic properties upon introduction of an alkyne moiety.
Авторлар туралы
E. Yamansarov
Department of Chemistry, M. V. Lomonosov Moscow State University
Хат алмасуға жауапты Автор.
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
I. Saltykova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
S. Kovalev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
R. Petrov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
D. Shkil’
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Seleznev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991
A. Majouga
Department of Chemistry, M. V. Lomonosov Moscow State University; National University of Science and Technology MISIS; D. Mendeleev University of Chemical Technology of Russia
Email: jamansar@gmail.com
Ресей, 3 Build., 1 Leninskie Gory, Moscow, 119991; 4 Leninskii prosp., Moscow, 119049; 1 Build., 9 Miusskaya pl., Moscow, 125047