Synthesis and cytotoxicity of new alkyne derivatives of pentacyclic triterpenoids
- Авторы: Yamansarov E.1, Saltykova I.1, Kovalev S.1, Petrov R.1, Shkil’ D.1, Seleznev E.1, Beloglazkina E.1, Majouga A.1,2,3
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Учреждения:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- National University of Science and Technology MISIS
- D. Mendeleev University of Chemical Technology of Russia
- Выпуск: Том 68, № 4 (2019)
- Страницы: 855-861
- Раздел: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243357
- DOI: https://doi.org/10.1007/s11172-019-2496-1
- ID: 243357
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Аннотация
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined against HepG2 and Huh7 hepatocarcinoma cells and PC3 prostate cancer cells. The primary analysis of the structure—activity relationships was performed; glycyrrhetic acid derivatives showed the maximum enhancement in the cytotoxic properties upon introduction of an alkyne moiety.
Об авторах
E. Yamansarov
Department of Chemistry, M. V. Lomonosov Moscow State University
Автор, ответственный за переписку.
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
I. Saltykova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
S. Kovalev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
R. Petrov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
D. Shkil’
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Seleznev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
E. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991
A. Majouga
Department of Chemistry, M. V. Lomonosov Moscow State University; National University of Science and Technology MISIS; D. Mendeleev University of Chemical Technology of Russia
Email: jamansar@gmail.com
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119991; 4 Leninskii prosp., Moscow, 119049; 1 Build., 9 Miusskaya pl., Moscow, 125047