Synthesis of N-(N-bromoacetylglycyl)-β-D-glycopyranosylamines, derivatives of monoand di-α-L-fucosylated diand trisaccharides
- 作者: Likhosherstov L.1, Novikova O.1, Kolotyrkina N.1, Berezin B.2, Piskarev V.2
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隶属关系:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- 期: 卷 66, 编号 4 (2017)
- 页面: 717-720
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240481
- DOI: https://doi.org/10.1007/s11172-017-1798-4
- ID: 240481
如何引用文章
详细
N-(N-Bromoacetylglycyl)-β-glycopyranosylamines of diand trisaccharides, namely, α-LFucp-(1→6)-β-D-GlcNAcp-NHCOCH2NHCOCH2Br, α-L-Fucp-(1→3)-β-D-GlcNAcpNHCOCH2NHCOCH2Br, α-L-Fucp-(1→6)-[α-L-Fucp-(1→3)]-β-D-GlcNAcp-NHCOCH2NHCOCH2Br, α-L-Fucp-(1→4)-[β-D-Galp-(1→3)]-β-D-GlcNAcp-NHCOCH2NHCOCH2Br, and α-L-Fucp-(1→2)-β-D-Galp-(1→4)-β-D-Glcp-NHCOCH2NHCOCH2Br, were synthesized in ~70% yields by treatment of the appropriate N-glycyl-β-glycopyranosylamines with N-bromoacetoxysuccinimide in aqueous DMF. The synthesized diand trisaccharide bromo derivatives are proposed for the obtaining of neoglycoconjugates of physiologically active substances, for instance, of daunorubicin anticancer agent.
作者简介
L. Likhosherstov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: likhosherstov@mail.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
O. Novikova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: likhosherstov@mail.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
N. Kolotyrkina
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: likhosherstov@mail.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
B. Berezin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: likhosherstov@mail.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991
V. Piskarev
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: likhosherstov@mail.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991