Synthesis of N-(N-bromoacetylglycyl)-β-D-glycopyranosylamines, derivatives of monoand di-α-L-fucosylated diand trisaccharides
- Авторы: Likhosherstov L.1, Novikova O.1, Kolotyrkina N.1, Berezin B.2, Piskarev V.2
-
Учреждения:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Выпуск: Том 66, № 4 (2017)
- Страницы: 717-720
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240481
- DOI: https://doi.org/10.1007/s11172-017-1798-4
- ID: 240481
Цитировать
Аннотация
N-(N-Bromoacetylglycyl)-β-glycopyranosylamines of diand trisaccharides, namely, α-LFucp-(1→6)-β-D-GlcNAcp-NHCOCH2NHCOCH2Br, α-L-Fucp-(1→3)-β-D-GlcNAcpNHCOCH2NHCOCH2Br, α-L-Fucp-(1→6)-[α-L-Fucp-(1→3)]-β-D-GlcNAcp-NHCOCH2NHCOCH2Br, α-L-Fucp-(1→4)-[β-D-Galp-(1→3)]-β-D-GlcNAcp-NHCOCH2NHCOCH2Br, and α-L-Fucp-(1→2)-β-D-Galp-(1→4)-β-D-Glcp-NHCOCH2NHCOCH2Br, were synthesized in ~70% yields by treatment of the appropriate N-glycyl-β-glycopyranosylamines with N-bromoacetoxysuccinimide in aqueous DMF. The synthesized diand trisaccharide bromo derivatives are proposed for the obtaining of neoglycoconjugates of physiologically active substances, for instance, of daunorubicin anticancer agent.
Об авторах
L. Likhosherstov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: likhosherstov@mail.ru
Россия, 47 Leninsky prosp., Moscow, 119991
O. Novikova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: likhosherstov@mail.ru
Россия, 47 Leninsky prosp., Moscow, 119991
N. Kolotyrkina
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: likhosherstov@mail.ru
Россия, 47 Leninsky prosp., Moscow, 119991
B. Berezin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: likhosherstov@mail.ru
Россия, 28 ul. Vavilova, Moscow, 119991
V. Piskarev
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: likhosherstov@mail.ru
Россия, 28 ul. Vavilova, Moscow, 119991