Chitosan modified with terephthaloyl diazide as a drug delivery system

A. V. Odinokov; D. Yu. Dzhons; A. V. Budruev; A. E. Mochalova; L. A. Smirnova

doi:10.1007/s11172-016-1423-y

Chitosan modified with terephthaloyl diazide as a drug delivery system

作者: Odinokov A.¹, Dzhons D.¹, Budruev A.¹, Mochalova A.¹, Smirnova L.¹
隶属关系:
1. N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
期: 卷 65, 编号 4 (2016)
页面: 1122-1130
栏目: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/237967
DOI: https://doi.org/10.1007/s11172-016-1423-y
ID: 237967

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅存取

详细
作者简介
参考
统计

详细

pH- and thermo-sensitive hydrogels based on chitosan cross-linked with terephthaloyl diazide were synthesized. A new formulation of the polysaccharide modified with taxifolin (dihydroquercetin) was obtained by nucleophylic addition reaction resulting in the formation of urea and urethane bonds with a 1,4-phenylenediamine spacer. Sustained release of the effective agent (flavonoid) upon action of trypsin, which is one of the enzymes of the gastrointestinal tract, was observed.