Chitosan modified with terephthaloyl diazide as a drug delivery system

A. V. Odinokov; D. Yu. Dzhons; A. V. Budruev; A. E. Mochalova; L. A. Smirnova

doi:10.1007/s11172-016-1423-y

Chitosan modified with terephthaloyl diazide as a drug delivery system

Авторлар: Odinokov A.¹, Dzhons D.¹, Budruev A.¹, Mochalova A.¹, Smirnova L.¹
Мекемелер:
1. N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Шығарылым: Том 65, № 4 (2016)
Беттер: 1122-1130
Бөлім: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/237967
DOI: https://doi.org/10.1007/s11172-016-1423-y
ID: 237967

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Статистика

Аннотация

pH- and thermo-sensitive hydrogels based on chitosan cross-linked with terephthaloyl diazide were synthesized. A new formulation of the polysaccharide modified with taxifolin (dihydroquercetin) was obtained by nucleophylic addition reaction resulting in the formation of urea and urethane bonds with a 1,4-phenylenediamine spacer. Sustained release of the effective agent (flavonoid) upon action of trypsin, which is one of the enzymes of the gastrointestinal tract, was observed.

Негізгі сөздер

chitosan, terephthaloyl diazide, chemical modification, taxifolin, hydrogel formation, drug delivery system, enzymatic hydrolysis, trypsin, sustained release, oral administration