Chitosan modified with terephthaloyl diazide as a drug delivery system
- Авторы: Odinokov A.1, Dzhons D.1, Budruev A.1, Mochalova A.1, Smirnova L.1
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Учреждения:
- N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
- Выпуск: Том 65, № 4 (2016)
- Страницы: 1122-1130
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237967
- DOI: https://doi.org/10.1007/s11172-016-1423-y
- ID: 237967
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Аннотация
pH- and thermo-sensitive hydrogels based on chitosan cross-linked with terephthaloyl diazide were synthesized. A new formulation of the polysaccharide modified with taxifolin (dihydroquercetin) was obtained by nucleophylic addition reaction resulting in the formation of urea and urethane bonds with a 1,4-phenylenediamine spacer. Sustained release of the effective agent (flavonoid) upon action of trypsin, which is one of the enzymes of the gastrointestinal tract, was observed.
Об авторах
A. Odinokov
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Россия, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
D. Dzhons
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Россия, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
A. Budruev
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Автор, ответственный за переписку.
Email: budruev@gmail.com
Россия, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
A. Mochalova
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Россия, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
L. Smirnova
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Россия, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950