Synthesis of substituted fulvenes with inden-2-ylphosphonic acid fragments

Аннотация

We have developed preparative methods for the synthesis of substituted fulvenes including inden-2-ylphosphonic acid fragments, as well as aromatic and heterocyclic substituents, based on bis(trimethylsilyl)inden-2-ylphosphonate and substituted azomethines in the presence of sodium hydride as an efficient initiator of the reaction. Subsequent treatment of the phosphonates with methanolic solution of sodium methoxide furnished water-soluble disodium salts of the corresponding phosphonic acids.