Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles

V. B. Sokolov; A. Yu. Aksinenko; T. V. Goreva; T. A. Epishina; L. G. Dubova; E. S. Dubrovskaya; S. G. Klochkov; P. N. Shevtsov; E. F. Shevtsova; S. O. Bachurin

doi:10.1007/s11172-016-1582-x

Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles

Авторы: Sokolov V.¹, Aksinenko A.¹, Goreva T.¹, Epishina T.¹, Dubova L.¹, Dubrovskaya E.¹, Klochkov S.¹, Shevtsov P.¹, Shevtsova E.¹, Bachurin S.¹
Учреждения:
1. Institute of Physiologically Active Substances, Russian Academy of Sciences
Выпуск: Том 65, № 9 (2016)
Страницы: 2306-2311
Раздел: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/239019
DOI: https://doi.org/10.1007/s11172-016-1582-x
ID: 239019

Цитировать

Полный текст

Открытый доступ
Доступ закрыт

Доступ предоставлен
Доступ закрыт

Только для подписчиков

Аннотация
Об авторах
Список литературы
Статистика

Аннотация

Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5Н-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.