Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles
- Authors: Sokolov V.B.1, Aksinenko A.Y.1, Goreva T.V.1, Epishina T.A.1, Dubova L.G.1, Dubrovskaya E.S.1, Klochkov S.G.1, Shevtsov P.N.1, Shevtsova E.F.1, Bachurin S.O.1
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Affiliations:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Issue: Vol 65, No 9 (2016)
- Pages: 2306-2311
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239019
- DOI: https://doi.org/10.1007/s11172-016-1582-x
- ID: 239019
Cite item
Abstract
Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5Н-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.
About the authors
V. B. Sokolov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
T. V. Goreva
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
T. A. Epishina
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
L. G. Dubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
E. S. Dubrovskaya
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
S. G. Klochkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
P. N. Shevtsov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
E. F. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
S. O. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432