Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles
- Авторлар: Sokolov V.1, Aksinenko A.1, Goreva T.1, Epishina T.1, Dubova L.1, Dubrovskaya E.1, Klochkov S.1, Shevtsov P.1, Shevtsova E.1, Bachurin S.1
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Мекемелер:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Шығарылым: Том 65, № 9 (2016)
- Беттер: 2306-2311
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239019
- DOI: https://doi.org/10.1007/s11172-016-1582-x
- ID: 239019
Дәйексөз келтіру
Аннотация
Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5Н-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.
Авторлар туралы
V. Sokolov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Aksinenko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
T. Goreva
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
T. Epishina
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
L. Dubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
E. Dubrovskaya
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
S. Klochkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
P. Shevtsov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
E. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
S. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432