Chitosan modified with terephthaloyl diazide as a drug delivery system

A. V. Odinokov; D. Yu. Dzhons; A. V. Budruev; A. E. Mochalova; L. A. Smirnova

doi:10.1007/s11172-016-1423-y

Chitosan modified with terephthaloyl diazide as a drug delivery system

Autores: Odinokov A.¹, Dzhons D.¹, Budruev A.¹, Mochalova A.¹, Smirnova L.¹
Afiliações:
1. N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Edição: Volume 65, Nº 4 (2016)
Páginas: 1122-1130
Seção: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/237967
DOI: https://doi.org/10.1007/s11172-016-1423-y
ID: 237967

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Resumo

pH- and thermo-sensitive hydrogels based on chitosan cross-linked with terephthaloyl diazide were synthesized. A new formulation of the polysaccharide modified with taxifolin (dihydroquercetin) was obtained by nucleophylic addition reaction resulting in the formation of urea and urethane bonds with a 1,4-phenylenediamine spacer. Sustained release of the effective agent (flavonoid) upon action of trypsin, which is one of the enzymes of the gastrointestinal tract, was observed.

Palavras-chave

chitosan, terephthaloyl diazide, chemical modification, taxifolin, hydrogel formation, drug delivery system, enzymatic hydrolysis, trypsin, sustained release, oral administration