Мақаланы E-mail арқылы жіберу Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties
- Авторлар: Butov G.1, Burmistrov V.1, Danilov D.1, Averin A.2, Morisseau C.3, Kodani S.3, Hammock B.3
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Мекемелер:
- Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
- M. V. Lomonosov Moscow State University
- Department of Entomology and UCD Cancer Center, University of California
- Шығарылым: Том 65, № 9 (2016)
- Беттер: 2299-2305
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239012
- DOI: https://doi.org/10.1007/s11172-016-1581-y
- ID: 239012
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Adamantyl-containing 1,3-disubstituted ureas, bisureas, and biscarbamates containing different spacers between the ureylene or the carbamate groups and the adamantyl radical were synthesized. Their inhibitory activity against soluble epoxide hydrolases of mammals and humans (sEH, E.C. 3.3.2.10) was studied. The compounds were found to possess high inhibitory activity on the level of 0.8—2.7 nmol L–1. A relationship between the inhibitor structure and its activity was established.
Авторлар туралы
G. Butov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Хат алмасуға жауапты Автор.
Email: butov@volpi.ru
Ресей, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
V. Burmistrov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
Ресей, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
D. Danilov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
Ресей, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
A. Averin
M. V. Lomonosov Moscow State University
Email: butov@volpi.ru
Ресей, 1 Leninskie Gory, Moscow, 119991
C. Morisseau
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
АҚШ, One shields avenue, California, Davis, 95615
S. Kodani
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
АҚШ, One shields avenue, California, Davis, 95615
B. Hammock
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
АҚШ, One shields avenue, California, Davis, 95615
