Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties
- 作者: Butov G.1, Burmistrov V.1, Danilov D.1, Averin A.2, Morisseau C.3, Kodani S.3, Hammock B.3
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隶属关系:
- Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
- M. V. Lomonosov Moscow State University
- Department of Entomology and UCD Cancer Center, University of California
- 期: 卷 65, 编号 9 (2016)
- 页面: 2299-2305
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239012
- DOI: https://doi.org/10.1007/s11172-016-1581-y
- ID: 239012
如何引用文章
详细
Adamantyl-containing 1,3-disubstituted ureas, bisureas, and biscarbamates containing different spacers between the ureylene or the carbamate groups and the adamantyl radical were synthesized. Their inhibitory activity against soluble epoxide hydrolases of mammals and humans (sEH, E.C. 3.3.2.10) was studied. The compounds were found to possess high inhibitory activity on the level of 0.8—2.7 nmol L–1. A relationship between the inhibitor structure and its activity was established.
作者简介
G. Butov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
编辑信件的主要联系方式.
Email: butov@volpi.ru
俄罗斯联邦, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
V. Burmistrov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
俄罗斯联邦, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
D. Danilov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
俄罗斯联邦, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
A. Averin
M. V. Lomonosov Moscow State University
Email: butov@volpi.ru
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
C. Morisseau
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
美国, One shields avenue, California, Davis, 95615
S. Kodani
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
美国, One shields avenue, California, Davis, 95615
B. Hammock
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
美国, One shields avenue, California, Davis, 95615