Email this article Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties
- Authors: Butov G.M.1, Burmistrov V.V.1, Danilov D.V.1, Averin A.D.2, Morisseau C.3, Kodani S.3, Hammock B.D.3
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Affiliations:
- Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
- M. V. Lomonosov Moscow State University
- Department of Entomology and UCD Cancer Center, University of California
- Issue: Vol 65, No 9 (2016)
- Pages: 2299-2305
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239012
- DOI: https://doi.org/10.1007/s11172-016-1581-y
- ID: 239012
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Abstract
Adamantyl-containing 1,3-disubstituted ureas, bisureas, and biscarbamates containing different spacers between the ureylene or the carbamate groups and the adamantyl radical were synthesized. Their inhibitory activity against soluble epoxide hydrolases of mammals and humans (sEH, E.C. 3.3.2.10) was studied. The compounds were found to possess high inhibitory activity on the level of 0.8—2.7 nmol L–1. A relationship between the inhibitor structure and its activity was established.
About the authors
G. M. Butov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Author for correspondence.
Email: butov@volpi.ru
Russian Federation, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
V. V. Burmistrov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
Russian Federation, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
D. V. Danilov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
Russian Federation, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
A. D. Averin
M. V. Lomonosov Moscow State University
Email: butov@volpi.ru
Russian Federation, 1 Leninskie Gory, Moscow, 119991
C. Morisseau
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
United States, One shields avenue, California, Davis, 95615
S. Kodani
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
United States, One shields avenue, California, Davis, 95615
B. D. Hammock
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
United States, One shields avenue, California, Davis, 95615
