Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones
- Authors: Il’ina I.V.1,2, Korchagina D.V.1, Morozova E.A.1, Tolstikova T.G.1, Volcho K.P.1,2, Salakhutdinov N.F.1,2
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Affiliations:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Issue: Vol 68, No 5 (2019)
- Pages: 1061-1066
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243381
- DOI: https://doi.org/10.1007/s11172-019-2520-5
- ID: 243381
Cite item
Abstract
A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.
About the authors
I. V. Il’ina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: volcho@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
D. V. Korchagina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
E. A. Morozova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
T. G. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
K. P. Volcho
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Author for correspondence.
Email: volcho@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
N. F. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: volcho@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090