Enviar artigo por via de e-mail Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones
- Autores: Il’ina I.1,2, Korchagina D.1, Morozova E.1, Tolstikova T.1, Volcho K.1,2, Salakhutdinov N.1,2
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Afiliações:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Edição: Volume 68, Nº 5 (2019)
- Páginas: 1061-1066
- Seção: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243381
- DOI: https://doi.org/10.1007/s11172-019-2520-5
- ID: 243381
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Resumo
A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.
Sobre autores
I. Il’ina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: volcho@nioch.nsc.ru
Rússia, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
D. Korchagina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Rússia, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
E. Morozova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Rússia, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Rússia, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
K. Volcho
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Autor responsável pela correspondência
Email: volcho@nioch.nsc.ru
Rússia, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: volcho@nioch.nsc.ru
Rússia, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
